Direct Deprotonative Functionalization of α,α‐Difluoromethyl Ketones using a Catalytic Organosuperbase

The deprotonative functionalization of α,α-difluoromethyl ketones is described herein. Using a catalytic organosuperbase and silane additive, the corresponding difluoroenolate could be generated trapped with aldehydes to deliver various α,α-difluoro-β-hydroxy in high yields. This new strategy tolerates numerous functional groups represents access by direct deprotonation difluoromethyl unit. diastereoselective version reaction was also investigated d.r. up 93 : 7. Several transformations were performed demonstrate synthetic potential these ketones. In addition, this method has been extended use other electrophiles such as imines chalcogen derivatives, sulfoxide nucleophile, thus leading diversity difluoromethylene compounds.